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目的:探讨辅助生殖技术(assisted reproductive technology,ART)治疗后流产的发生率及其相关因素。方法:回顾性分析2008年6月～2011年12月在郑州大学第三附属医院生殖医学中心接受ART治疗后获得临床妊娠的558例患者,比较流产组和分娩组之间的年龄、体重指数(BMI)、不孕年限、促性腺激素使用天数(Gn天数)和总量(Gn总量)、获卵数、移植胚胎数、孕囊数和基础内分泌之间的流产率。结果:流产率年龄>35岁组明显高于<35岁组(P<0.01);BMI≥25 kg/m2组高于BMI<25 kg/m2组(P<0.05);随着移植胚胎数的增加,多胎率和流产率均增加;流产组的基础PRL高于分娩组。结论:ART治疗后流产的发生可能与患者的年龄、BMI、移植胚胎数、基础PRL相关。
Objective: To investigate the incidence of abortion after assisted reproductive technology (ART) and its related factors. Methods: A retrospective analysis of 558 patients with clinical pregnancy after receiving ART treatment at the Reproductive Medicine Center of the Third Affiliated Hospital of Zhengzhou University from June 2008 to December 2011 was performed. The age and body mass index BMI, duration of infertility, number of gonadotrophin days (Gn days) and total (Gn total), number of oocytes retrieved, number of embryos transferred, number of gestational sacs and basal endocrine. Results: Abortion rate was significantly higher in the group of 35 years old than in the group of 35 years old (P <0.01); The BMI≥25 kg / m2 was higher than that in the group of BMI <25 kg / m2 (P <0.05) Increase, multiple birth rate and abortion rate increased; abortion group basic PRL higher than the delivery group. Conclusion: The incidence of abortion after ART treatment may be related to patient’s age, BMI, number of embryos transferred and basic PRL.