论文部分内容阅读
应用胞核团内微量注射和核团电刺激方法，观察杏仁基底内侧核（BMA）对胃运动的影响，分析BMA与下丘脑腹内侧核（VMH）的机能联系。结果如下：（1）双侧BMA内注射八肽胆囊收缩素（CCK-8）（50ng/lμl），出现胃内压（IGP）和胃运动频率（GMF）显著下降（P＜0.01）。（2）BMA内注射CCK-A受体阻断剂［L364，718］（10ng／μl）或CCK－B受体阻断剂［L365，260」（100ng／lμl），IGP和GMF无明显影响。（3）先给予［L364，718］（10ng/lμl），再给予CCK－8，IGP和GMF的抑制不再出现；而先给［L365，260］，则CCK－8对IGP和GMF的抑制仍出现。（4）在BMA附近如终纹床核杏仁内侧部（BSTIA）和内侧杏仁核（Me）注射CCK-8均未出现IGP和GMP的抑制作用。（5）分别电刺激单侧BMA和VMH，均显著降低IGP和GMF。（6）电损毁单侧VMH后，电刺激同侧BMA或BMA内微量注射CCK-8均不能降低IGP和GMF。这些结果揭示：BMA内CCK－8对IGP和GMF有抑制作用，这种抑制作用是通过BMA内的CCK-A受体激活而实现，CCK-B受体可能不参与。在BMA抑制胃运动的传出通路中,VMH是必须的中介环节。
The effect of BMA on gastric motility was observed by microinjection of nuclei and nucleus electrostimulation. The functional relationship between BMA and ventromedial hypothalamic nucleus (VMH) was analyzed. The results were as follows: (1) The intragastric pressure (IGP) and gastric motility frequency (GMF) of CCK-8 (50ng / lμl) were significantly decreased in bilateral BMA injection group (P <0.01). (2) IGP and GMF had no significant effect on BMA injection of CCK-A receptor blockers [L364,718] (10ng / μl) or CCK-B receptor blockers [L365,260 "(100ng / lμl) . (3) [L364,718] (10ng / lμl), followed by CCK-8, inhibition of IGP and GMF no longer occurred; while [L365,260], CCK-8 inhibited IGP and GMF Still appear (4) No inhibition of IGP and GMP was observed in the vicinity of the BMA, such as BSTIA and CCK-8 in the medial amygdala. (5) Electrical stimulation of unilateral BMA and VMH, respectively, significantly reduced IGP and GMF. (6) After unilateral VMH was electrically damaged, neither IGP nor GMF could be reduced by electrical stimulation of CCK-8 in ipsilateral BMA or BMA. These results revealed that CCK-8 inhibits IGP and GMF in BMA by activating CCK-A receptors within BMA and CCK-B receptors may not be involved. VMH is a necessary mediator in BMA’s efferent pathways that inhibit gastric motility.