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纳洛酮(Naloxone,NX)是人工合成的特异性阿片受体拮抗剂,近年广泛用于治疗伴有阿片肽类生理功能失调的各种疾病,本文仅就国内部分最新资料,慨述如下。 1 治疗阿片类药物中毒,诊断阿片类药物依赖 NX对麻醉镇痛药吗啡、哌替啶、海洛因、芬太尼等引起的呼吸抑制具有特异性拮抗作用,且起效快,疗效好。邓先容等报道吗啡类中毒5例,入院时已有不同程度的意识障碍和呼吸抑制,用NX后均在5h内出院。周桂莲等新近报道,对严重呼吸抑制(包括1例呼吸停止)的急性海洛因中毒者
Naloxone (NX), a synthetic opioid receptor antagonist, has been widely used in the treatment of various diseases associated with opioid physiological dysfunction in recent years. This article is only based on the latest domestic data. 1 treatment of opioid poisoning, diagnosis of opioid dependence NX on the narcotic analgesics morphine, pethidine, heroin, fentanyl and other respiratory depression caused by specific antagonism, and rapid onset, good effect. Deng Xianrong and other reports of morphine poisoning in 5 cases, admission has varying degrees of disturbance of consciousness and respiratory depression, were discharged within 5h after NX. Zhou Guilian and other recently reported, severe respiratory depression (including 1 case of respiratory arrest) of acute heroin poisoning