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目的 本研究旨在观察调胃冲剂对功能性消化不良 (FD)相关发病机制的影响 ,为临床应用提供理论依据。方法 以小鼠、大鼠为实验对象 ,以吗丁啉为阳性对照药物观察调胃冲剂对其胃排空、促小肠动力以及对胃粘膜的保护作用。结果 与对照组比较调胃冲剂对胃排空、促小肠动力以及对胃粘膜的保护作用优于对照组 (P <0 .0 1)。结论 调胃冲剂除具有与吗丁啉相似的促胃动力作用外 ,高剂量组还具有全消化道促动力作用。而且对乙醇所致胃粘膜损害有明显的保护作用
Objectives The purpose of this study was to observe the effect of Tiaowan Granules on the pathogenesis of functional dyspepsia (FD) and provide a theoretical basis for clinical application. Methods Mice and rats were used as experimental subjects, and Motilium was used as a positive control drug to observe the protective effects of Tiaowan Granule on gastric emptying, intestinal motility and gastric mucosa. Results Compared with the control group, Tiaowan Granule had better effects on gastric emptying, intestinal motility, and gastric mucosa than the control group (P < 0.01). Conclusion In addition to the gastric motility effect similar to Motilium, Tiaogan granules also have the role of full digestive tract motility. And it has obvious protective effect on ethanol-induced gastric mucosal damage