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分泌性天门冬酸蛋白酶是白念珠菌的毒力因子之一,该菌以此酶分解宿主蛋白来供自身营养,在分解皮肤粘膜屏障组织中,促进了菌对宿主组织的粘附,破坏了免疫屏障是真菌侵入宿主的重要成分。故抑制减少此酶的分泌及活力的抗念珠菌药物具有重要意义。目前具有上述特征的抗真菌药物中有5-氟胞嘧啶及酚康唑(fenticonazole),近来又发现一种含N~3-(4-甲羟基延胡索酰)-L-2,3-二氨基丙酸(FMDP)残基的合成寡肽对鼠系统念珠菌病模型十分有效。作者对FMDP-肽(即Lys-Nva-FMDP)在体外对天冬氨酸蛋白酶分泌的影响作了研究。
Secretory aspartic acid protease is one of the virulence factors of Candida albicans, the enzyme to break down the host protein for its own nutrition, in the decomposition of skin and mucous membrane barrier tissue, promote the adhesion of bacteria to the host tissue, destroyed Immune barrier is an important component of the fungus invade the host. Therefore, inhibition of reducing the secretion of this enzyme and vitality of anti-Candida drugs has important significance. Among the anti-fungal drugs currently having these characteristics are 5-fluorocytosine and fenticonazole. Recently, an antifungal agent containing N ~ 3- (4-menthylsuccinate) -L-2,3-diamino Synthesis of Propionic Acid (FMDP) Residues Oligopeptides are very effective in murine systemic candidiasis models. The authors investigated the effect of FMDP-peptide (ie, Lys-Nva-FMDP) on the secretion of aspartic protease in vitro.