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目的探讨疏血通注射液干预脑梗死出现的药物不良反应。方法 78例脑梗死住院患者,随机分为观察组和对照组,各39例。观察组给予疏血通治疗,对照组给予常规治疗。观察两组患者临床事件观察以及不良反应情况,采用副反应量表评价不良反应情况。结果两组患者临床事件比较,差异无统计学意义(P>0.05)。治疗后观察组副反应量表评分为(4.59±0.23)分,对照组为(13.82±0.49)分,两组比较差异具有统计学意义(P<0.01)。观察组患者中共出现5例不良反应,其中寒战2例、出血1例,进行因果关系评价,结果为“很可能”。血小板升高1例、恶心1例,因果评价为“可能”。结论疏血通注射液治疗脑梗死可能与其改善血液流变学有关,但使用过程中可能引发血小板升高、寒战等不良反应,临床使用本品时应注意药物的用量及频次。
Objective To investigate the adverse effects of Shuxuetong injection on cerebral infarction. Methods 78 cases of cerebral infarction hospitalized patients were randomly divided into observation group and control group, 39 cases each. The observation group was given Shuxuetong treatment, while the control group was given routine treatment. Observation of clinical events and adverse reactions in two groups of patients, the adverse reaction was assessed using the side effects scale. Results There was no significant difference in clinical events between the two groups (P> 0.05). After treatment, the score of adverse reaction in the observation group was (4.59 ± 0.23) points, while that in the control group was (13.82 ± 0.49) points. The differences between the two groups were statistically significant (P <0.01). There were 5 adverse reactions in the observation group, including 2 cases of chills and 1 case of hemorrhage. The causal relationship was evaluated and the result was “Most likely ”. 1 case of thrombocytopenia, 1 case of nausea, causal evaluation as “possible”. Conclusion Shuxuetong injection for the treatment of cerebral infarction may be related to its improvement of hemorheology, but may lead to thrombocytopenia during use, chills and other adverse reactions, the clinical use of this product should pay attention to the dosage and frequency of drugs.