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将56名活动性十二指肠溃疡随机分为两纽,其中哌吡酮组35例,给予哌吡酮150mg/d,曱氰咪胍组21例,给邓甲氰眯胍800mg/d。治疗6周后内镜复查,发现溃疡愈合率分别为68.6%胍71.4%;总的有效率为82.9%及85.7%,P>0.05。止痛效果哌吡酮略优于甲氰咪胍组,但无统计学差异。哌吡酮为选择性毒蕈碱受体阻滞剂,但仍有33/35例出现不同程度度的口干,19/35例出现视力模糊,但不影响正常治疗,是可逆性的。我们认为国产哌吡酮不失为一安全有效的抗消化性溃疡新药。
Fifty-six active duodenal ulcers were randomly divided into two groups: 35 in the group of piperacillin, 150 mg / kg of eplerenone and 21 in the cimetidine group. d. After 6 weeks of treatment, the endoscopic examination showed that the healing rates of ulcer were 68.6% and 71.4%, respectively. The total effective rates were 82.9% and 85.7%, respectively, P> 0.05. The analgesic effect of piperazinone slightly better than the cimetidine group, but no significant difference. As the selective muscarinic blockers, 33/35 of them still had different degrees of dry mouth, and 19 of 35 cases had blurred vision, which did not affect the normal treatment and were reversible. We believe that domestic piperpirone can be a safe and effective new anti-peptic ulcer drugs.