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根据在一定时间内药物粒径的分布变化,可测得未溶解粒子的表面积和重量,进而计算药物的溶解量和溶解速率的原理,作者曾用库尔特计数器测定了两种难溶性药物在混悬液中的溶解度和溶解速率。当药物的溶解度低于5ppm时,可用更细的药物粒子来进行试验以提高方法的灵敏度。但受库尔特计数器的最低检出粒度0.5μm所限制。为此作者试验了不影响试液导电性,不干扰试验物的粒子计数,与体内生理环境相似的表面活性剂的胶束液,用库尔特计数器测定了具有1ppm甚至更低溶解度药物的溶解度和比表溶解速率。
According to the changes in the distribution of drug particle size in a certain period of time, the surface area and weight of undissolved particles can be measured, and then the principle of dissolution and dissolution rate of the drug can be calculated. The authors used the Coulter counter Solubility and dissolution rate in suspension. When drug solubility is below 5 ppm, finer drug particles can be used to test to increase the sensitivity of the method. But is limited by the minimum detectable particle size of the Kurt counter of 0.5 μm. To do this, the authors tested the micellar solution of surfactants that did not affect the conductivity of the test solution, did not interfere with the test particles, and the physiological environment in vivo. The Coulter counter measured the solubility of the drug with a solubility of 1 ppm or less And specific surface dissolution rate.