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目前,对于类风湿关节炎(rheumatoid arthritis,RA)发病机制的研究虽然并不完全清晰,但过去20多年的研究已经使我们对RA的了解增加了很多。遗传因素对RA有很大的影响,但不足以完全解释RA的发生。随着对菌群与RA关系的了解增多,使我们认识到可以利用调节人体菌群的方法,来改善宿主黏膜及更远处的免疫环境以改善RA。目前研究已表明,RA与多个部位的菌群都有一定的关系。本研究将以RA的发病机制与影响因素为基础,对人体口腔、肺部和肠道的菌群变化对类风湿关节炎的影响以及益生菌的治疗作用进行综述。
At present, although the research on the pathogenesis of rheumatoid arthritis (RA) is not entirely clear, the research over the past 20 years has greatly increased our understanding of RA. Genetic factors have a great impact on RA, but not enough to completely explain the occurrence of RA. With the increased understanding of the relationship between the flora and RA, we have realized that we can use the method of regulating the body flora to improve the mucosa in the host and the immune environment further away to improve RA. The current research has shown that RA has a certain relationship with the bacteria in multiple parts. This study will be based on the pathogenesis of RA and influencing factors, the impact of human oral cavity, lung and intestinal flora changes on rheumatoid arthritis and the therapeutic effect of probiotics are reviewed.