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目的观察中西医结合治疗小儿支气管哮喘慢性持续期的临床疗效及对免疫功能的影响。方法将122例支气管哮喘慢性持续期患儿随机分为治疗组62例与对照组60例,对照组给予孟鲁司特钠咀嚼片治疗,治疗组在对照组治疗方法的基础上结合肃肺平肝养阴汤治疗。治疗4周后统计2组的临床疗效,治疗前、后肺功能指标和免疫功能指标水平的变化,不良反应发生情况。结果对照组总有效率为75.00%,治疗组为91.94%,2组比较差异有统计意义(P<0.05)。2组治疗前第1秒用力呼气容积(FEV_1)和用力肺活量(FVC)经统计学分析,差异均无统计意义(P>0.05);治疗后2组FEV_1和FVC均显著升高,与同组治疗前比较,差异均有统计意义(P<0.05),且治疗组升高幅度均大于对照组(P<0.05)。2组治疗前免疫球蛋白(Ig)A,IgM,IgE,IgG水平比较,差异均无统计意义(P>0.05);治疗后2组IgA,IgM水平均升高,IgE水平下降,与同组治疗前比较,差异均有统计意义(P<0.05),且治疗组改善幅度大于对照组(P<0.05)。IgG治疗前后差异无统计意义(P>0.05)。2组均未见不良反应情况发生。结论中西医结合治疗小儿支气管哮喘慢性持续期疗效显著,可显著改善患儿的免疫功能,且安全可靠,值得临床推广。
Objective To observe the clinical efficacy of traditional Chinese and western medicine in treating children with chronic bronchial asthma and its effect on immune function. Methods A total of 122 children with chronic persistent bronchial asthma were randomly divided into treatment group (62 cases) and control group (60 cases). The control group was treated with montelukast sodium chewable tablets. The treatment group was treated with sufentanil Liver Yang Yin treatment. After 4 weeks of treatment, the clinical curative effects of the two groups were statistically analyzed. The changes of the indexes of pulmonary function and immune function before and after treatment, and the occurrence of adverse reactions were observed. Results The total effective rate of the control group was 75.00%, the treatment group was 91.94%, the difference between the two groups was statistically significant (P <0.05). FEV 1 and FVC were not significantly different between the two groups before treatment (P> 0.05); FEV_1 and FVC were significantly increased in both groups after treatment Group before treatment, the difference was statistically significant (P <0.05), and the treatment group increased more than the control group (P <0.05). The levels of IgA, IgM, IgE and IgG in two groups had no significant difference before treatment (P> 0.05). After treatment, the levels of IgA and IgM in both groups increased and the level of IgE decreased, Before treatment, the differences were statistically significant (P <0.05), and the treatment group improved more than the control group (P <0.05). There was no significant difference in IgG before and after treatment (P> 0.05). No adverse reactions occurred in 2 groups. Conclusion Integrative treatment of bronchial asthma in children with chronic persistent significant effect, can significantly improve children’s immune function, and safe and reliable, worthy of clinical promotion.