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A group of experimental rats under free radical damage are given various amounts of a lipophilic vitamin C(ascorbyl-6-laurate, VC-12), and its parent compound, vitamin C, respectively. It has been found that the effects of 1 12 mmol/kg VC-12 on decreasing triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol (LDL-c) and lipid peroxide(LPO), and increasing high density lipoprotein cholesterol(HDL-c) and superoxide dismutase(SOD) are similar to those of 2 27 mmol/kg vitamin C. In addition, VC-12(1 12 mmol/kg) can increase the prostacycline(PGI 2) and decrease the thromboxane(TXA 2) even better than vitamin C(2 27 mmol/kg). The above facts demonstrate that the antioxidative activity of VC-12 is higher than twice that of vitamin C. So, ascorbyl-6-laurate may be a novel antioxidant drug against free radical damage.
A group of experimental rats under free radical damage are given various amounts of a lipophilic vitamin C (ascorbyl-6-laurate, VC-12), and its parent compound, vitamin C, respectively. It has been found that the effects of 1 12 mmol / kg VC-12 on decreasing triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c) and lipid peroxide (LPO), and increasing high density lipoprotein cholesterol (HDL-c) and superoxide dismutase SOD) were similar to those of 27 mmol / kg vitamin C. In addition, VC-12 (12 mmol / kg) could increase the prostacycline (PGI 2) and decrease the thromboxane (TXA 2) even better than vitamin C 2 27 mmol / kg). The above facts demonstrate that the antioxidant activity of VC-12 is higher than twice that of vitamin C. So, ascorbyl-6-laurate may be a novel antioxidant drug against free radical damage.