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许多研究表明,健康人群常规接种乙型肝炎血源疫苗后,92～99%产生对 HBsAg 的抗体反应。为了使接种后抗体反应发生率尽可能达到最高水平,有人建议对无反应或反应低下者进行重复接种,但尚无明确方案。本文报道常规接种3次乙型疫苗无反应或反应低下者,加种3次疫苗后的效果。831名乙型肝炎表面抗原(HBsAg)与抗-HBs均阴性的健康医院工作人员,常规接种乙型血源疫苗,每次剂量20μg,经三角肌或股四头肌肌注,共3次
Numerous studies have shown that 92-99% of HBsAg antibodies are produced by healthy volunteers after routine inoculation of hepatitis B vaccine. In order to maximize the incidence of antibody responses after inoculation, it has been suggested that repeated vaccinations should be given to those who have no response or to those who do not respond to it, but no specific plan is available. This article reports the routine inoculation of 3 times the B vaccine without response or low response, add 3 times after the vaccine effect. 831 healthy hospital staff who were negative for HBsAg and anti-HBs were routinely inoculated with blood-borne type B vaccine at a dose of 20 μg per dose and intramuscular injection of the deltoid or quadriceps muscles for 3 times