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应用免疫增强剂“425”和α-干扰素经腹腔注射已经感染日本血吸虫小鼠,用药后14～29天,注射“425”小鼠,肝组织内特异性抗体(IgG)水平显著高于对照组(P<0.01或0.05),肝虫卵内芽肿反应增长比也显著地小于对照组(P<0.01);注射a-干扰素小鼠,肝虫卵肉芽肿反应增长比也显著地小于对照组(P<0.01),但小鼠肝组织内特异性抗体(IgG)水平与对照组之间无显著性差异(P>0.05)说明免疫增强剂“425“和α-干扰素可能通过体液免疫和细胞免疫不同途径的抑制或作用,使虫卵肉芽肿病变减弱。
Infection of mice with Schistosoma japonicum was performed by intraperitoneal injection of immunostimulant ”425“ and α-interferon. After injection of ”425“ mice 14 to 29 days after administration, the level of specific IgG in liver tissue was significantly higher than that of the control Group (P <0.01 or 0.05), and the growth ratio of intrahepatic ovarian granuloma reaction was also significantly less than that of the control group (P <0.01). The ratio of growth of hepatic worm egg granuloma reaction was also significantly smaller than that of the control group (P <0.01), but there was no significant difference (P> 0.05) between the levels of specific IgG in the liver tissue of the mice and the control group (P> 0.05), indicating that the immune enhancers ”425" Humoral and cellular immunity in different ways to inhibit or effect, so that egg granuloma lesion lesion.