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目的研究与胃癌相关的血清癌胚抗原(CEA)、糖链抗原19-9(CA19-9)、糖链抗原72-4(CA72-4)3种肿瘤标志物在胃癌诊断中的价值。方法对76例胃癌患者、28例健康人血清采用化学发光法检测CEA值,采用放射免疫法检测CA19-9、CA72-4值。结果胃癌患者血清中CEA、CA19-9、CA72-4与正常人比较差异有统计学意义(P<0.01),CEA、CA19-9、CA72-4单独检测时敏感性分别为59.2%、44.7%、46.1%,联合检测CA19-9及CA72-4特异性为63.15%,3项联合检测的特异性达71.1%。结论3种肿瘤标志物联合检测可提高胃癌诊断的特异性和有效性。
Objective To investigate the value of serum carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 72-4 (CA72-4) in the diagnosis of gastric cancer. Methods Serum CEA was measured by chemiluminescence in 76 patients with gastric cancer and 28 healthy controls. The levels of CA19-9 and CA72-4 were detected by radioimmunoassay. Results The serum levels of CEA, CA19-9 and CA72-4 in patients with gastric cancer were significantly lower than those in healthy controls (P <0.01). The sensitivity of CEA, CA19-9 and CA72-4 alone were 59.2% and 44.7% , 46.1%. The specificity of combined detection of CA19-9 and CA72-4 was 63.15%. The specificity of the three combined detection was 71.1%. Conclusion The combined detection of three tumor markers can improve the specificity and effectiveness of the diagnosis of gastric cancer.