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:【目的】观察错配修复基因产物hMSH2在涎腺良恶性组织中的表达。【方法】应用免疫组化技术检测正常和炎症涎腺、多形性腺瘤、粘液表皮样癌、腺样囊性癌和腺癌组织的hMSH2表达。【结果】hMSH2在正常和炎症涎腺组织导管上皮细胞的胞核、胞浆阳性表达 ,在腺样囊性癌和腺癌肿瘤细胞的胞核呈强阳性表达 ,但在多型性腺瘤、粘液表皮样癌组织不表达。【结论】部分涎腺肿瘤组织出现错配修复基因产物hMSH2的表达异常
: 【Objective】 To observe the expression of mismatch repair gene product hMSH2 in benign and malignant salivary glands. 【Methods】 The expression of hMSH2 in normal and inflammatory salivary glands, pleomorphic adenomas, mucoepidermoid carcinoma, adenoid cystic carcinoma and adenocarcinoma was detected by immunohistochemistry. 【Results】 The positive expression of hMSH2 in the nucleus and cytoplasm of normal and inflammatory salivary gland ductal epithelial cells was strongly positive in the nuclei of adenoid cystic carcinoma and adenocarcinoma tumor cells. However, in the cases of pleomorphic adenoma, mucus Epidermoid carcinoma tissue is not expressed. 【Conclusion】 The expression of mismatch repair gene product hMSH2 in some salivary gland tumors was abnormal