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目的:观察昂丹司琼对化疗相关性恶心、呕吐的预防作用。方法:32例癌症患者在化疗前静推昂丹司琼8mg,每日1次,预防化疗相关性恶心、呕吐反应,并与西沙必利和多潘立酮预防者对比。结果:昂丹司琼组32例,共完成48个疗程,恶心呕吐反应为1.17±l.63度,较西沙必利和多潘立酮组低(分别为2.74±0.74度和2.86±0.64度,P<0.01);无明显药物不良反应。结论:昂丹司琼对化疗所致恶心、呕吐有明显的预防作用。
Objective: To observe the preventive effect of ondansetron on the chemotherapy-related nausea and vomiting. Methods: Thirty two patients with oncology were given statin therapy with ondansetron 8 mg once daily to prevent chemotherapy-related nausea and vomiting, and compared with cisapride and domperidone prophylaxis. Results: In the ondansetron group, 32 patients completed a total of 48 courses of treatment with a nausea and vomiting response of 1.17 ± 1.63 degrees compared with cisapride and domperidone groups (2.74 ± 0.74 and 2.86 ± 0.64, respectively, P <0.01 ); No obvious adverse drug reactions. Conclusion: Ondansetron has obvious preventive effect on nausea and vomiting caused by chemotherapy.