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目的 :探讨持续静脉输注诺维本治疗转移性乳腺癌的疗效及不良反应。方法 :全组 18例 ,先行锁骨下静脉穿刺置管 ,安置微量静脉泵 ,用NP方案化疗 ,即诺维本 (NVB) 10mg静注d1,然后 10mg/d以微量静脉泵持续静脉输注 (civ) ,连续 5天 ;顺铂 4 0mg静脉滴注d1～ 3,每 4周重复。化疗过程中注意观察不良反应 ,连用 2周期后评价疗效。结果 :18例患者 ,治疗后PR 7例、NC 8例、PD 3例 ,有效率为 38 9% ;在 6 3个化疗周期中 ,18个周期化疗后发生白细胞减少 ,占 2 8 6 % ,无静脉炎发生。结论 :NVB持续静脉输注联合顺铂治疗转移性乳腺癌疗效较好 ,不良反应减轻。
Objective: To investigate the efficacy and adverse reactions of continuous intravenous infusion of Novubiben in the treatment of metastatic breast cancer. Methods: All 18 patients underwent subclavian vein catheterization, micro venous pump, NP regimen, ie NVB 10 mg intravenously d1, then 10 mg / d continuous intravenous infusion civ) for 5 consecutive days; cisplatin 40mg intravenously d1 ~ 3, repeated every 4 weeks. Adverse reactions observed during chemotherapy, once every 2 weeks after the evaluation of efficacy. Results: In 18 patients, there were 7 cases of PR after treatment, 8 cases of NC and 3 cases of PD with an effective rate of 38 9%. Leukopenia occurred after 18 cycles of chemotherapy in 6 3 cycles, accounting for 286% No phlebitis occurred. Conclusion: Continuous intravenous infusion of NVB combined with cisplatin in the treatment of metastatic breast cancer is effective and adverse reactions are relieved.