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目的观察2011年1月-2013年3月收治的自身免疫性肝病患者的临床特点、隐匿性乙型肝炎病毒(HBV)感染以及相关影响因素,为探索更有效的早期发现自身免疫性肝病提供依据。方法选取2011年1月-2013年3月门诊及住院诊断为自身免疫性肝病的81例患者为观察对象,根据患者不同亚型分为自身免疫性肝炎组(AIH组)23例、原发性胆汁性肝硬化组(PBC组)9例及原发性硬化胆管炎组(PSC组)49例,并选取门诊健康体检者87例作为对照组,比较4组人群不同亚型的自身免疫性肝病患者隐匿性HBV感染情况。结果 AIH组男女比例为1∶22,PSC组为1∶3.5,PBC组为1∶23.5,女性多于男性;≥50岁的老年患者较多;AIH组、PSC组、PBC组3组患者隐匿性HBV感染率分别是13.04%、11.11%、16.33%,高于健康对照组(P<0.05);HBV检测阳性与患者的性别、年龄以及血清IGG、血清IGM等指标之间,差异无统计学意义。结论自身免疫性肝病的临床表现特点与国内报道研究结果相近,老年女性好发,抗体阳性表达率为75.51%;且ALD患者隐匿性HBV感染率较高。
Objective To observe the clinical features, occult hepatitis B virus (HBV) infection and related factors in patients with autoimmune liver disease admitted from January 2011 to March 2013 and provide the basis for exploring more effective early detection of autoimmune liver disease . Methods From January 2011 to March 2013, 81 patients diagnosed as autoimmune liver disease in outpatients and inpatients were divided into three groups: autoimmune hepatitis (AIH) group (23 cases), primary Nine patients with biliary cirrhosis (PBC) and 49 patients with primary sclerosing cholangitis (PSC), and 87 healthy subjects were selected as the control group, and the four subgroups of autoimmune liver disease Patients with occult HBV infection. Results The ratio of male to female in the AIH group was 1:22, in the PSC group was 1: 3.5, in the PBC group was 1: 23.5, in the female group was higher than that in the male group; in the elderly group of more than 50 years old, the AIH group, the PSC group and the PBC group were occluded The positive rate of HBV infection was 13.04%, 11.11% and 16.33%, respectively, which was higher than that of healthy control group (P <0.05). There was no significant difference between HBV positive test and gender, age, serum IGG and serum IGM significance. Conclusions The clinical manifestations of autoimmune liver disease are similar to those reported in China. The positive rate of antibody positive expression in elderly women is 75.51%. The prevalence of occult HBV infection in ALD patients is high.