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胰高血糖素样肽1(GLP-1)是肠道L细胞分泌的肠促胰岛素激素,具有葡萄糖浓度依赖型降糖作用及β细胞保护作用,同时还具有减重、降压和降脂等心血管系统保护作用。艾塞那肽和利拉鲁肽均是天然GLP-1类似物,利拉鲁肽与人GLP-1同源性更高,且为长效制剂,它们克服了天然GLP-1易被降解的特点,保留了GLP-1的各种生理作用和治疗优势,发挥GLP-1的多效作用,降糖、β细胞保护、减重、降压、调脂全面干预多种心血管危险因素,且低血糖风险低,安全性好。GLP-1在治疗2型糖尿病及防治心血管风险方面具有独特优势。
Glucagon-like peptide 1 (GLP-1) is an incretin hormone secreted by intestinal L cells. Glucagon-like peptide 1 (GLP-1) is a glucagon-dependent hypoglycemic agent and a β cell protector. Cardiovascular system protection. Both exenatide and liraglutide are natural GLP-1 analogs and liraglutide is more homologous to human GLP-1 and is a long acting formulation that overcomes the tendency of native GLP-1 to degrade Features, retains the GLP-1 a variety of physiological effects and treatment advantages, play a multi-role of GLP-1, hypoglycemic, β-cell protection, weight loss, blood pressure, lipid regulation comprehensive intervention of a variety of cardiovascular risk factors Low risk of hypoglycemia, good safety. GLP-1 has unique advantages in treating type 2 diabetes and preventing cardiovascular risks.