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头孢匹姆(Cefepime,CBMY-28142)为头孢类抗生素,对革兰氏阳性菌(包括金黄色葡萄球菌)及革兰氏阴性菌(包括绿脓杆菌等)均有抗菌作用。对各种细菌产生的β-内酰胺酶均极稳定,由于其亲和性低,故耐药性菌株少。静注本品后,可得到较高的血药浓度,且血药浓度与给药量成正比,半减期约1.8小时,24小时内80%以原形经肾排泄。复杂性尿路感染44例、急性前列腺炎1例,每次静滴本品0.5～1g,每日2次,共给
Cefepime (CBMY-28142) is a cephalosporin antibiotic that has antibacterial activity against Gram-positive bacteria (including Staphylococcus aureus) and Gram-negative bacteria (including Pseudomonas aeruginosa, etc.). The β-lactamase produced by various bacteria is extremely stable, and has few drug-resistant strains because of its low affinity. After intravenous injection of this product, higher plasma concentration can be obtained, and the plasma concentration is proportional to the dosage. The half-period of about 1.8 hours, 80% within 24 hours to the prototype by the renal excretion. Complex urinary tract infection in 44 cases, 1 case of acute prostatitis, each intravenous 0.5 ~ 1g of the product, 2 times a day, a total of