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目的:探讨人附睾蛋白4(HE4)对卵巢恶性肿瘤鉴别及与病理特征的关系。方法:收治卵巢肿瘤患者210例,分为观察1组、观察2组。选取健康女性100例作为对照组。检测3组的血清HE4水平。结果:观察1组血清HE4水平明显高于观察2组、对照组,差异具有统计学意义(P<0.05)。观察2组血清HE4水平与对照组间相比,差异无统计学意义(P>0.05)。低分化级阳性率高于中高分化级阳性率,早期卵巢癌阳性率低于晚期卵巢癌阳性率,差异具有统计学意义(P<0.05)。结论:HE4是较好的诊断卵巢恶性肿瘤的标志物,其水平与病理特征具有一定的相关性。
Objective: To investigate the relationship between human epididymis 4 (HE4) and malignant ovarian tumor and its pathological characteristics. Methods: Totally 210 ovarian cancer patients were divided into observation group 1 and observation group 2. 100 healthy women were selected as the control group. Serum HE4 levels were measured in 3 groups. Results: The level of serum HE4 in observation group 1 was significantly higher than that in observation group 2 and control group (P <0.05). There was no significant difference in HE4 level between the two groups (P> 0.05). The positive rate of poorly differentiated grade was higher than that of moderately-differentiated grade, the positive rate of early ovarian cancer was lower than that of advanced ovarian cancer, the difference was statistically significant (P <0.05). Conclusion: HE4 is a good marker of ovarian cancer. The level of HE4 is correlated with pathological features.