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在一种新的大鼠加速性弥漫性脑损伤模型基础上,采用抽血造成低血压,及高热形成二次脑创伤,探讨二次脑创伤鼠脑海马细胞外液兴奋性氨基酸(EAA)含量变化及意义。32只SD大鼠随机分为假手术对照、脑损伤、二次脑创伤及脑损伤并二次脑创伤四组。所有动物均实施同步生理监护。结果:二次创伤后1h,与假手术组对比,损伤组未见EAA含量增高;单纯二次脑创伤组及合并二次脑创伤组EAA含量均增高(P<0.05)。单纯二次脑创伤组及合并二次脑创伤组EAA含量均增高,提示其参予脑损伤病理过程,与原发性脑损伤加重有关。
Based on a new type of rat model of accelerated diffuse brain injury, hypothalamus was induced by blood drawing and secondary brain injury was formed by hyperthermia. The content of excitatory amino acid (EAA) Change and significance. Thirty-two Sprague-Dawley rats were randomly divided into four groups: sham operation control, brain injury, secondary brain injury, brain injury and secondary brain injury. All animals are synchronized physiological monitoring. Results: Compared with the sham operation group, no EAA level was found in the injury group at 1 hour after trauma. The EAA levels in both the secondary traumatic brain injury group and the secondary traumatic brain injury group were significantly increased (P <0.05). The levels of EAA in pure secondary brain trauma group and secondary traumatic brain injury group were both higher, suggesting that it may be involved in the pathological process of brain injury, which is associated with the aggravation of primary brain injury.