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标题化合物(1)是合成11-去羟前列腺素E_1(PGE_1)及其衍生物的重要中间体。在引入羟基后所得化合物2是用1,4-加成法合成PGE_1及其衍生物的关键中间体。因此最近几年文献中对合成1的研究仍有不少报道。我们曾从环戊酮合成1。现在本文报道另一种合成1的方法。一般应用Grignard试剂与酰氯反应制备酮时,由于会进一步生成叔醇而使实际应用受到限制。Stowell发现2-(2′-溴乙基)1,3-二氧六环(3)的Grignard试剂与酰氯的反应可以完全控制在形成酮的阶段,因此我们使用3的Grignard试剂与壬二酸单乙酯的酰
The title compound (1) is an important intermediate for the synthesis of 11-dehydroxy prostaglandin E 1 (PGE 1) and its derivatives. The resulting compound 2 is the key intermediate for the synthesis of PGE 1 and its derivatives using 1,4-addition. Therefore, there are still many reports on the synthesis of 1 in the literature in recent years. We have synthesized 1 from cyclopentanone. We now report on another method of synthesizing 1. General application Grignard reagent and acyl chloride reaction of ketones, due to the further formation of tertiary alcohol and the actual application is limited. Stowell found that the reaction of the Grignard reagent of 2- (2’-bromoethyl) 1,3-dioxane (3) with an acid chloride can be completely controlled at the ketogenic stage, so we use 3 Grignard reagent with azelaic acid Acyl monoethyl ester