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目的:优化清火栀麦口服液的提取工艺。方法:采用二次回归正交试验设计方法,以脱水穿心莲内酯和栀子苷含量为评价指标,用高效液相色谱法测定提取液中脱水穿心莲内酯与栀子苷含量并对清火栀麦口服液的提取工艺进行优化。结果:最佳提取工艺为用11倍量的68%乙醇浸渍穿心莲和栀子药材2次,每次29h;麦冬采用8倍量蒸馏水回流提取2次,每次1h,醇沉浓度为80%。结论:该工艺稳定、操作简便、合理可行。
Objective: To optimize the extraction process of Qinghuizhuomai Oral Liquid. Methods: The quadratic regression orthogonal design method was used. The contents of dehydroandrographolide and geniposide were evaluated. The content of dehydroandrographolide and geniposide in the extract was determined by high performance liquid chromatography Mai oral solution extraction process optimization. Results: The best extraction process was impregnated with 68% ethanol with 11 times the amount of andrographis paniculata 2 times, each 29h; Ophiopogon 8 times the amount of distilled water by reflux extraction 2 times, each time 1h, the alcohol sediment concentration was 80% . Conclusion: The process is stable, easy to operate, reasonable and feasible.