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目的:探讨PET-CT模拟定位对非小细胞肺癌合并肺不张适形调强放疗靶区确定的临床价值。方法:对经影像学和病理证实伴有肺不张的非小细胞肺癌12例患者,进行PET-CT模拟定位。根据PET-CT扫描显像结果,分别以GTVCT和GTVPET-CT勾画原发病灶,对用治疗计划系统计算出的两组数值加以比较。结果:GTVCT平均为141 cm3(99~185 cm3),GTVPET-CT平均为113 cm3(60~165 cm3),两者差异有显著性(t=5.497,P<0.001)。12例患者原发病灶体积的GTVPET-CT均较GTVCT有不同程度的缩小,平均缩小体积28 cm3(19%)。结论:PET-CT模拟定位,对非小细胞肺癌合并肺不张患者放疗靶区的精确定位具有重要的临床意义。
Objective: To investigate the clinical value of PET-CT mimicry in the determination of target area of atrial fibrillation-modulated radiation therapy in patients with non-small cell lung cancer. Methods: Twelve patients with non-small cell lung cancer with atelectasis confirmed by imaging and pathology were studied with PET-CT. According to PET-CT scan imaging results, the primary lesions were delineated by GTVCT and GTVPET-CT respectively, and the two groups of values calculated by the treatment planning system were compared. Results: The average GTVCT was 141 cm3 (99-185 cm3) and GTVPET-CT was 113 cm3 (60-165 cm3). The difference was significant (t = 5.497, P <0.001). The GTVPET-CT volume of 12 patients with primary lesion volume was reduced to some extent compared with that of GTVCT, with an average reduction volume of 28 cm3 (19%). Conclusion: The PET-CT simulated localization has important clinical significance for the accurate localization of radiotherapy target in non-small cell lung cancer patients with atelectasis.