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A new 1,4-dihydroquinoline compound, 2’-thioxo-2’,3’-dihydro-1’H,2H-spiro [naphtho[2,1-b]furan-1,5’-pyrimido[4,5-b]quinoline]-2,4’(10’H)-dione(C22H13N3O3S), has been synthesized by the condensation of isatin, 2-thiobarbituric acid and 2-naphthol in aqueous medium. The compound was characterized by IR, NMR, H RMS and single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group P21/c with a = 9.5187(18), b = 11.7706(19), c = 12.0450(19) ?, α = 89.201(5), β = 81.550(6), γ = 70.024(5)°, Mr = 399.41, V = 1253.6(4) ?3, Z = 2, Dc = 1.058 g/cm3, F(000) = 412, μ = 0.151 mm-1, R = 0.0636 and w R = 0.1648. The preliminary antibacterial activity results show that the title compound exhibits antibacterial activity against Micrococcus tetragenus, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, S. albus and Escherichia coli.
A new 1,4-dihydroquinoline compound, 2’-thioxo-2 ’, 3’-dihydro- 1’H, 2H- spiro [naphtho [2,1- b] furan-1,5’-pyrimido [4,5 -b] quinoline] -2,4 ’(10’H) -dione (C22H13N3O3S), has been synthesized by the condensation of isatin, 2-thiobarbituric acid and 2-naphthol in aqueous medium. The compound was characterized by IR, NMR , H RMS and single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group P21 / c with a = 9.5187 (18), b = 11.7706 (19), c = 12.0450 (19) 89.201 (5), β = 81.550 (6), γ = 70.024 (5) °, Mr = 399.41, V = 1253.6 (4)? 3, Z = 2, Dc = 1.058 g / cm3, F , μ = 0.151 mm-1, R = 0.0636 and w R = 0.1648. The preliminary antibacterial activity results show that the title compound exhibits antibacterial activity against Micrococcus tetragenus, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, S. albus and Escherichia coli.