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目的 探讨精神分裂症患者跨期决策能力是否受损,及其未发病一级亲属是否也存在一定程度上跨期决策能力的受损.方法 选取25例精神分裂症患者,25名患者未发病的一级亲属及30名与年龄、教育程度相匹配的健康对照者,采用延迟折扣(Delay-discount)中文版实验范式评价跨期决策能力、成套的神经心理学测试分析三组神经心理学特征.折扣率k值反映跨期决策能力.结果 患者组,亲属组及对照组的k值分别为(0.005±0.009),(0.011±0.014),(0.024±0.029),差异有统计学意义(F=9.487,P＜0.001);其中患者组与对照组、亲属组与对照组之间差异均有统计学意义(均P＜0.05),而患者组与亲属组差异无统计学意义(P＞0.05).k值与一般神经心理学背景测试之间相关性差异均无统计学意义(P＞0.05).结论 精神分裂症患者跨期决策能力受损,未发病一级亲属也存在一定程度上跨期决策能力的损伤.“,”Objective To explore whether the ability of intertemporal choice is impaired in schizophrenic patients and in their unaffected siblings.Methods Twenty-five schizophrenia patients,twenty-five unaffected siblings of patients and thirty healthy controls were recruited in the study.“Delay-discounting” task and a battery of cognitive neuropsychological assessment were used to examine the intertemporal decision-making.Results (1) the value of k was ((0.005±0.009 in schizophrenia,0.011±0.014 in unaffected siblings and 0.024±0.029 in healthy controls,respectively.There was significant difference in k value among these three groups (F=9.487,P＜0.001).There were significant differences in k value between patients group and healthy controls,and between unaffected siblings and healthy controls (P＜0.05).There was no significant difference between schizophrenia and their unaffected siblings (P＜0.05).(2) Pearson correlation analysis not showed any relationship between neuropsychological test and the value of k.Conclusion The ability of intertemporal choices is impaired in schizophrenia and their unaffected siblings to a great degree.