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采用 1∶1配比病例对照研究方法 ,将 4 2例临床确诊为周围型肺癌而TBLB检查为“假阴性”的病例 ,同时配以TBLB检查为“阳性”的周围性肺癌病例对照进行分析 ,探求导致TBLB检查假阴性的影响因素。多因素条件Logistic回归分析表明 :肿块≤ 2cm、空洞病灶、一些特殊部位病灶、活检时标本粒数≤ 3块 ,为与TBLB假阴性相关的独立危险因素。镜下见间接征象、重复检查为有保护性作用的影响因素。单因素分析还表明 :术前胸痛症状与TBLB假阴性有关 (P <0 .0 5 )。
A case-control study with a ratio of 1: 1 was used to compare 42 cases of peripheral lung cancer diagnosed as “false negative” with TBLB and a case-control study of peripheral lung cancer with “positive” TBLB. To explore the factors leading to false negative results of TBLB examination. Multivariate Logistic regression analysis showed that the lesions were ≤ 2 cm in size, empty lesions and some special lesions were detected. The number of specimens with biopsy was ≤ 3, which was an independent risk factor associated with false negative TBLB. See the indirect signs of the microscope, repeat the test for the protective effect of factors. Univariate analysis also showed that preoperative chest pain was associated with false negative TBLB (P <0.05).