NLRP3炎症小体在机体脂质代谢中的作用研究进展

来源 :中国药理学与毒理学杂志 | 被引量 : 0次 | 上传用户：yy20090907

【摘要】

：

在世界范围内,肥胖人口正逐年增加并呈现年轻化趋势,伴随增加了许多疾病风险如脂肪肝、2型糖尿病等。在肥胖患者的机体中,脂肪组织作为内分泌组织分泌脂肪因子,并促进巨噬细胞及其他免疫细胞的募集和浸润,释放炎症细胞因子和趋化因子,最终导致炎症并影响机体代谢。核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体是一种蛋白复合体,胞质内由多种蛋白构成,可通过激活胱天蛋白酶1,释放IL^-1β和IL^-18等炎症因子,发挥炎症效应。机体脂质代谢紊乱与NLRP3炎症小体密切相关

【作者】

：

贺润铖黄芷棋冯倩倩董世芬

【机构】

：

北京中医药大学中药学院中药药理系

【出处】

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中国药理学与毒理学杂志

【发表日期】

：

2021年10期

【关键词】

：

NLRP3炎症小体脂质代谢肥胖炎症因子

【基金项目】

：

国家自然科学基金(81503287)。

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NLRP3炎症小体在机体脂质代谢中的作用研究进展

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