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目的探讨血管紧张素转换酶（ＡＣＥ）基因第１６内含子的插入／缺失（Ｉ／Ｄ）多态性与原发性高血压合并脑卒中的关系。方法应用聚合酶链反应（ＰＣＲ）扩增技术检测５０例原发性高血压合并脑卒中患者（脑卒中组），７８例原发性高血压和１５５例健康对照组。结果脑卒中组Ｉ型（５２％）显著高于对照组（３４％）（Ｐ＝０．０２５）。ＤＤ型（８％）远低于对照组（２０％）（Ｐ＝０．０４９）。而ＩＤ型则无明显差异。７８例原发性高血压组与对照组相比无显著差异。Ｉ等位基因频率在脑卒中组（７２％）显著高于对照组（５７％）（Ｐ＝０．００８），非脑卒中组与对照组相近。结论ＡＣＥ基因的插入／缺失多态性与原发性高血压合并脑卒中发病相关，Ｉ等位基因及Ｉ基因型可能为原发性高血压合并脑卒中的独立危险因素之一。
Objective To investigate the relationship between insertion / deletion (I / D) polymorphism of the 16th intron of angiotensin converting enzyme (ACE) gene and essential hypertension complicated with stroke. Methods Fifty patients with essential hypertension complicated with stroke (stroke group), 78 patients with essential hypertension and 155 healthy controls were detected by polymerase chain reaction (PCR) amplification. Results Stroke group I (52%) was significantly higher than the control group (34%) (P = 0.025). DD type (8%) was much lower than the control group (20%) (P = 0.049). The ID type is no significant difference. There was no significant difference between the 78 patients with essential hypertension and the control group. The frequency of the I allele was significantly higher in the stroke group (72%) than in the control group (57%) (P = 0.008). The non-stroke group was similar to the control group. Conclusion The insertion / deletion polymorphism of ACE gene is associated with the incidence of essential hypertension complicated with stroke. The I allele and I genotype may be one of the independent risk factors for hypertension complicated with stroke.