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作者报告1例十二指肠溃疡出血病人应用甲氰咪胍发生急性肝损伤的电镜观察及临床表现。患者男性,36岁,因上腹痛伴黑便于1979年7月13日入院,胃镜证实为十二指肠溃疡出血。血红蛋白12.9 g％,其它常规生化检查无特殊。谷草转氨酶(SGOT)、谷丙转氨酶(SGPT)、碱性磷酸酶(ALP)、胆红素、γ-谷氨酰转移酶(GGT)均正常,乙型肝炎表面抗原(HBsAg)阴性。既往史无特殊,否认用药、吸烟及过敏反应史,每天饮酒约40g。体检正常。入院次日起,口服甲氰咪胍1 g/d,未用其它药物及输血。4周后内窥镜见溃疡已愈合,血红蛋白15.2g％,
The authors report a case of duodenal ulcer bleeding patients with cimetidine acute liver injury by electron microscopy and clinical manifestations. The patient, male, 36 years old, was admitted to hospital on July 13, 1979 due to the presence of upper abdominal pain. Gastroscopy confirmed bleeding from duodenal ulcer. Hemoglobin 12.9 g%, other conventional biochemical tests no special. SGOT, SGPT, ALP, bilirubin and GGT were normal, and HBsAg negative. No previous history, denied medication, smoking and allergic reaction history, drinking about 40g daily. Physical examination is normal. From the next day after admission, Cimetidine 1 g / d was orally administered without any other drugs and blood transfusions. 4 weeks after the endoscopic ulcers have been seen to heal, hemoglobin 15.2g%