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HBV在我国人群的感染率为31.6～61.56%。目前携带HBV者占全国人口的7～12%。尤其是HBV复制指标阳性的孕妇,其婴儿的HBV感染率达75～100%。HBV与肝硬化及肝癌的发生又有较密切的关系。但至今国内外抗HBV治疗尚无理想的药物。于1989年初我们试用HBV-TF联合大剂量乙肝疫苗治疗慢性HBV感染者22例,对照组18例。报道如下: 病例选择与一般资料:1989年1月～11月住院或门诊HBsAg(+)超过半年以上,并有HBcAg(+)或PHSA-R(+)的患者或携带者共40例。随机分治疗组22例,对照组18例。治疗组男18(对照组14)例,女4(4)例。平均年龄34.1(29.88)岁。HBV感染时间半年-10~+(半年-7)年。临床病型:C AH 11(11)例、CPH6
HBV infection rate in our population was 31.6 ~ 61.56%. Currently carrying HBV accounted for 7 to 12% of the national population. In particular, pregnant women with positive HBV replication markers have an HBV infection rate of 75-100% in infants. HBV and liver cirrhosis and the occurrence of liver cancer are more closely related. However, anti-HBV treatment at home and abroad so far there is no ideal drug. In early 1989 we tried HBV-TF combined with high-dose hepatitis B vaccine in patients with chronic HBV infection in 22 cases, 18 cases in the control group. Reported as follows: Case selection and general information: January 1989 to January inpatient or outpatient HBsAg (+) more than six months, and HBcAg (+) or PHSA-R (+) in 40 patients or carriers. Twenty-two patients were randomly divided into treatment group and control group. Treatment group male 18 (control group 14) and female 4 (4) cases. The average age was 34.1 (29.88) years old. HBV infection half a year -10 ~ + (half year -7) years. Clinical type: C AH 11 (11) cases, CPH6