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目的探讨HBsAg阳性母亲免疫球蛋白联合乙肝疫苗规律接种效果。方法选择130例患者,根据是否规律接种分为两组,其中观察组孕妇在孕28周及预产期前1周注射乙肝免疫球蛋白200 IU,新生儿按照体重使用0.5ml/kg,145 IU/ml乙肝免疫球蛋白注射并在出生时、出生后第1、6个月分别注射乙肝疫苗5μg,对照组则因为各种原因,在总计母体2次注射,新生儿4次注射中存在1次以上的未注射,在新生儿12月龄和18月龄分别检测小儿乙肝表面抗原抗体情况,并统计两组抗体滴度。结果 12月和18月龄时观察组乙肝表面抗原阳性检出率低于对照组(P<0.05),乙肝表面抗体阳性检出率高于对照组(P<0.05),且12月龄和18月龄乙肝表面抗体均高于对照组(P<0.05)。结论在孕中期和孕晚期规律注射乙肝免疫球蛋白并在新生儿出生后实施乙肝疫苗和免疫球蛋白联合注射能较好的达到母婴阻断效果。
Objective To investigate the regular vaccination effect of HBsAg positive maternal immunoglobulin combined with hepatitis B vaccine. Methods 130 patients were divided into two groups according to whether they were inoculated regularly or not. The pregnant women in the observation group were injected with 200 IU of hepatitis B immunoglobulin at 28 weeks of pregnancy and one week before the expected date of birth, and the neonates were given 0.5 ml / kg and 145 IU / ml of body weight Hepatitis B immunoglobulin injection and at birth, 1, 6 months after birth, were injected with hepatitis B vaccine 5μg, while the control group for various reasons, in a total of two maternal injections, four newborns injections there is more than one Uninjected, neonatal 12-month-old and 18-month-old were detected in children with hepatitis B surface antigen antibody and antibody titer in both groups. Results The positive rate of HBsAg in observation group was lower than that in control group at December and 18 months (P <0.05), and the positive rate of HBsAg positive was higher than that in control group (P <0.05) Month-old hepatitis B surface antibody were higher than the control group (P <0.05). Conclusion Regular hepatitis B immunoglobulin injection in the second trimester and the third trimester of pregnancy and the combination of hepatitis B vaccine and immunoglobulin injection after neonatal birth can better achieve the effect of blocking maternal and infant.