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前列腺素具有维护胃肠道粘膜的完整性和促进溃疡愈合的作用,其确切机理尚不明,可能与PGS(主要是PGE_2能促进胃的粘液和碳酸氢盐分泌,抑制胃酸分泌,以及增加胃粘膜血流,防止氢离子反弥散等因素有关.为了研究十二指肠溃疡患者十二指肠粘膜内PGE_2和其他前列腺素的合成和含量变化,作者对32例活动性十二指肠溃疡病和27例非溃疡病患者(因腹部症状而作纤维胃镜后诊断为肠道易激综合症)作了十二指肠粘膜活检并测定粘膜内前列腺素和血栓素A_2(TxA_2)的含量.
Prostaglandin has the function of maintaining the integrity of gastrointestinal mucosa and promoting the healing of ulcer. The exact mechanism is not clear. It may be related to PGS (mainly PGE_2), which can promote gastric mucus and bicarbonate secretion, inhibit gastric acid secretion and increase gastric mucosa Blood flow, to prevent the anti-diffusion of hydrogen ions and other factors.In order to study duodenal ulcer patients with duodenal mucosa PGE2 and other prostaglandin synthesis and content changes, the authors of 32 cases of active duodenal ulcer disease and Twenty-seven non-ulcer patients (diagnosed with irritable bowel syndrome after fibro-gastroscopy due to abdominal symptoms) were given a duodenal biopsy and the contents of prostaglandin and thromboxane A 2 (TxA 2) in the mucosa were determined.