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已有报告提示,用Ara-A(阿糖腺苷)治疗慢性乙型肝炎,对HBV相关的脱氧核糖核酸多聚酶(DNAP)有抑制作用,停用激素可导致DNAP下降。本文通过前瞻性对照研究,评价Ara-A和强的松龙停药以及两者单用或联合治疗慢性乙型肝炎的效果。接受研究的43例慢性乙型肝炎患者,HBeAg和DNAP活性均为阳性。进入研究前,所有患者都通过肝活检证实有慢性肝病,血清HBsAg、DNAP和HBeAg阳性皆在6个
It has been reported that the treatment of chronic hepatitis B with Ara-A (vidarabine) has an inhibitory effect on HBV-related DNA polymerase and the withdrawal of the hormone leads to a decrease in DNAP. This prospective, controlled, prospective study evaluated the effects of withdrawal from Ara-A and prednisolone and the combination of either alone or in combination in the treatment of chronic hepatitis B. Of the 43 patients with chronic hepatitis B who underwent the study, both HBeAg and DNAP activity were positive. Before entering the study, all patients were confirmed by chronic liver disease liver biopsy, serum HBsAg, DNAP and HBeAg were positive in 6