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肠道微环境稳态的维持依赖于肠道寄生的微生物与表皮细胞,基质细胞以及免疫细胞的共同作用。肠道表皮细胞在细菌与粘膜层免疫细胞之间建立了物理与生化的“栅栏”。它能够通过分泌抗菌因子以及调节粘膜免疫反应来对肠道的微生物施加影响。肠道免疫稳态的紊乱会伴随许多炎性疾病的出现,包括克罗恩氏病以及溃疡性肠炎。目前引起肠道炎症反应的机制仍不清楚。在肠道炎性反应中,肿瘤坏死因子(TNF)扮演了十分重要的角色、。TNF与受体结合后,会激活转录因子NF-KB的表达,从而促进细胞的存
The maintenance of intestinal microenvironment homeostasis relies on the interaction of intestinal parasitized microorganisms with epidermal cells, stromal cells, and immune cells. Intestinal epidermal cells establish a physical and biochemical “barrier” between bacterial and mucosal immune cells. It exerts its influence on intestinal microorganisms by secreting antibacterial factors and regulating mucosal immune responses. Intestinal immune homeostasis is accompanied by the appearance of many inflammatory diseases, including Crohn’s disease and ulcerative colitis. The mechanisms that cause the intestinal inflammatory response are still unclear. Tumor necrosis factor (TNF) plays a very important role in the intestinal inflammatory response. TNF and receptor binding, it will activate the transcription factor NF-KB expression, thereby promoting the survival of cells