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对85例慢性阻塞性肺疾病（COPD）患者进行了1s率（FEV1％），最大呼气中期流速（MMEF），血栓素B2（TXB2），6－酮－前列腺素F1a（6K－K－PGF1a），T淋巴细胞总数（T3）及亚群（T4，T8），IgA、G、M测定。结果：FEV1％降低，血浆中TXB2浓度升高，TXB2／6－K－PGF1a比值增大，外周血中T4减少，T8增多，T4／T8比值下降。MMEF重度降低时，TXB2和TXB2／6K－K－PGF1a升高，IgG改变显著，T4减少，T4／T8比值降低。T4／T8比值降低患者，血浆中TXB2浓度升高，TXB2／6－K－PGF1a比值增大，差异显著。结果提示：COPD患者可能有TXB2／6－K－PGF1a平衡紊乱，免疫功能改变，T4／T8比值改变可能影响TXB2／6－K－PGF1a平衡。大气道和小气道发生和发展机制不完全相同。
Eighty-five patients with chronic obstructive pulmonary disease (COPD) underwent 1s rate (FEV1%), maximum expiratory flow rate (MMEF), TXB2 and 6K-K-PGF1a ), T lymphocytes (T3) and subgroups (T4, T8), IgA, G, M were measured. Results: The FEV1% decreased, the concentration of TXB2 increased, the ratio of TXB2 / 6-K-PGF1a increased, T4 decreased, T8 increased and T4 / T8 decreased in peripheral blood. When MMEF decreased significantly, TXB2 and TXB2 / 6K-K-PGF1a increased, IgG changed significantly, T4 decreased and T4 / T8 ratio decreased. In patients with a lower T4 / T8 ratio, the TXB2 concentration in plasma increased and the ratio of TXB2 / 6-K-PGF1a increased significantly. The results suggest that the patients with COPD may have the disorder of TXB2 / 6-K-PGF1a, the change of immune function, the change of T4 / T8 ratio may affect the balance of TXB2 / 6-K-PGF1a. The mechanisms of occurrence and development of the airways and small airways are not exactly the same.