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为探讨低气压缺氧噪声性聋的治疗方法，采用模拟高原５０００ｍ、９５ｄＢＳＰＬ白噪声持续刺激４小时，造成豚鼠低气压缺氧噪声性聋的动物模型。用磷酸川芎嗪、复方丹参、地塞米松进行治疗。以ＡＢＲ反应阈、耳蜗毛细胞损伤率、扫描电镜下毛细胞的形态为指标，对治疗效果进行观察。发现对照组（未治疗组）与三个治疗组之间ＡＢＲ反应阈阈移、外毛细胞损伤率有高度显著性差异（Ｐ＜０．０１）。扫描电镜发现：三个治疗组低气压缺氧噪声刺激后４、８天外毛细胞形态基本正常。结果表明：上述三种药物对低气压缺氧噪声性聋有较好的治疗效果，并对其治疗机理进行了讨论。
To investigate the treatment of hypobaric hypoxia-induced noise-induced deafness, animal models of guinea pig hypobaric hypoxia noise-induced deafness were established by continuous stimulation with white noise of 5000m and 95dBSPL on simulated plateau for 4 hours. With ligustrazine phosphate, compound Salvia, dexamethasone for treatment. ABR response threshold, cochlear hair cell damage rate, morphology of hair cells under scanning electron microscopy as an indicator of the therapeutic effect was observed. It was found that there was a highly significant difference in ABR threshold threshold shift and outer hair cell damage between the control group (untreated group) and the three treatment groups (P <0.01). Scanning electron microscopy showed that the outer hair cells in the three treatment groups were basically normal at 4 and 8 days after hypoxia and hypoxia noise stimulation. The results showed that the above three drugs have a better therapeutic effect on hypobaric hypoxia noise-induced hearing loss and the treatment mechanism was discussed.