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[目的]观察羟基喜树碱(HCTP)、奥沙利铂(L-OHP)、5-氟脲嘧啶(5-Fu)联合治疗进展期胃癌的近期临床疗效。[方法]经手术或病理学证实为进展期胃癌患者60例,随机分成实验组用HCPT联合L-OHP5-Fu方案治疗进展期胃癌30例,对照组L-OHP联合5-Fu方案治疗进展期胃癌30例两组。化疗2周期以上,评价近期疗效及毒副反应情况。[结果]HCPT联合L-OHP5-Fu的实验组有效率为46.7%,明显高于L-OHP联合5-Fu的对照组,有效率为26.7%,两组比较差异有统计学意义(χ2=3.363,P=0.0339)。两组均有不同程度的胃肠道反应及骨髓抑制、口腔溃疡等不良反应(P﹥0.05),差异无统计学意义。[结论]HCPT联合L-OHP5-Fu方案治疗进展期胃癌疗效好,毒副反应轻,能耐受。
[Objective] To observe the short-term clinical efficacy of combination of HCT, L-OHP and 5-Fu in the treatment of advanced gastric cancer. [Methods] 60 cases of advanced gastric cancer confirmed by operation or pathology were randomly divided into experimental group (HCPT plus L-OHP5-Fu regimen) for advanced gastric cancer (30 cases) and control group (L-OHP plus 5-Fu regimen) Gastric cancer in 30 cases two groups. More than 2 cycles of chemotherapy, evaluation of the recent efficacy and side effects. [Results] The effective rate of HCPT combined with L-OHP5-Fu in experimental group was 46.7%, significantly higher than that of L-OHP combined with 5-Fu control group, the effective rate was 26.7%, the difference was statistically significant (χ2 = 3.363, P = 0.0339). Both groups had different degrees of gastrointestinal reactions and bone marrow suppression, oral ulcers and other adverse reactions (P> 0.05), the difference was not statistically significant. [Conclusion] HCPT combined with L-OHP5-Fu regimen is effective in treating advanced gastric cancer with light toxicity and tolerability.