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Neonatal sepsis is common in neonatal intensive care units,often complicated by injury to the immature brain. Previous studies have shown that the expression of the gap junction protein connexin 43(Cx43) in the brain decreases when stimulated by neuro-infl ammatory drugs such as lipopolysaccharide(LPS). Here we showed that partial deletion of Cx43 in astrocytes resulted in weakened inflammatory responses. The up-regulation of pro-inflammatory cytokines was significantly reduced in mice with partial deletion of Cx43 in astrocytes compared with wild-type littermates after systemic LPS injection. Moreover,microglial activation was inhibited in mice with partial deletion of Cx43. These results showed that Cx43 in astrocytes plays a critical role in neuro-infl ammatory responses. This work provides a potential therapeutic target for inhibiting neuroinfl ammatory responses in neonatal sepsis.
Neonatal sepsis is common in neonatal intensive care units, often complicated by injury to the immature brain. Previous studies have shown that the expression of the gap junction protein connexin 43 (Cx43) in the brain decreases when stimulated by neuro-infl ammatory drugs such as Here we showed that partial deletion of Cx43 in astrocytes resulted in weakened inflammatory responses. The up-regulation of pro-inflammatory cytokines was significantly reduced in mice with partial deletion of Cx43 in astrocytes compared with wild-type littermates after systemic These results showed that Cx43 in astrocytes plays a critical role in neuro-infl ammatory responses. This work provides a potential therapeutic target for inhibiting neuroinfl ammatory responses in neonatal sepsis .