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采用ELISA方法,测定17例伤寒患者急性期与恢复期血清白细胞介素-5(IL-5)的浓度,同时做嗜酸细胞计数,分析IL-5水平与嗜酸细胞数的关系,比较IL-5检出组与未检出组间的嗜酸细胞数、病情、病程的变化。结果显示IL-5水平与嗜酸细胞数呈正相关,IL-5检出组与未检出组间的嗜酸细胞数、发热持续时间、最高体温及病程间有明显差别。动态检测IL-5有助于了解机体免疫状况,评估病情及预后。
ELISA method was used to determine the concentration of serum interleukin-5 (IL-5) in 17 patients with typhoid fever during the acute phase and convalescent phase. At the same time, the eosinophil count was analyzed. The relationship between IL-5 level and eosinophil count was analyzed. IL -5 detected group and not detected group of eosinophil count, disease, course of disease changes. The results showed that there was a positive correlation between the level of IL-5 and the number of eosinophils. The number of eosinophils, the duration of fever, the maximum body temperature and the duration of disease were significantly different between IL-5-positive and non-detected groups. Dynamic detection of IL-5 helps to understand the immune status of the body to assess the condition and prognosis.