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目的了解微生态制剂(酪酸梭菌二联活菌散)防治婴幼儿肺炎继发腹泻的疗效。方法选取2008年1月至2010年12月收住清徐县第二人民医院呼吸科诊断为支气管肺炎继发腹泻的患儿共116例,随机分为2组,以住院期间抗生素治疗同时应用微生态制剂(酪酸梭菌二联活菌散)的患儿为治疗组60例,仅使用抗生素治疗的患儿为对照组56例,分别观察腹泻次数、大便性状、腹痛、止泻时间及大便镜检与大便培养正常时间及治疗有效率。结果微生态制剂(酪酸梭菌二联活菌散剂)治疗组腹泻次数减少时间、大便性状变稠时间、腹泻停止时间明显短于对照组(P<0.05),腹痛消失时间明显短于对照组(P<0.01),治疗组临床症状消失时间明显比对照组短;治疗组大便镜检恢复正常时间明显短于对照组(P<0.05),大便细菌培养恢复正常时间明显短于对照组(P<0.01),2组患儿治疗效果比较,治疗组有效率为91.67%,对照组有效率为76.79%,经卡方检验χ2=4.89,P<0.05,差异有统计学意义,治疗组有效率明显高于对照组。结论酪酸梭菌二联活菌散剂防治婴幼儿肺炎继发腹泻,能使腹泻时间缩短、疗效明显、方法简便,经济,易于患儿及父母接受。
Objective To understand the efficacy of probiotics (Clostridium butyricum) in prevention and treatment of secondary diarrhea in infants with pneumonia. Methods A total of 116 children admitted to the Second People’s Hospital of Qingxu County from January 2008 to December 2010 who were diagnosed as secondary bronchial pneumonia with diarrhea were randomly divided into two groups and treated with antibiotics during hospitalization Eczema (Clostridium butyricum) was used in the treatment group of 60 patients. The children treated with antibiotics alone were 56 cases in the control group. The frequency of diarrhea, stool trauma, abdominal pain, diarrhea time and stool mirror Examination and stool culture normal time and treatment efficiency. Results The reduction of diarrhea times, stool stool thickening time, diarrhea stopping time were significantly shorter in the treatment group than in the control group (P <0.05), and disappearance of abdominal pain was significantly shorter than that of the control group P <0.01). The disappearance time of clinical symptom in the treatment group was shorter than that in the control group. The recovery time of stool examination in the treatment group was significantly shorter than that in the control group (P <0.05), and the stool bacterial culture returned to normal time was significantly shorter than that in the control group (P < 0.01). The therapeutic effect of the two groups was 91.67% in the treatment group and 76.79% in the control group. The chi-square test showed that there was a significant difference between the two groups (χ2 = 4.89, P <0.05) Higher than the control group. Conclusions Clostridium butyricum biomonad is effective in prevention and treatment of diarrhea secondary to pneumonia in infants and young children. It can shorten the diarrhea time and has obvious curative effect. The method is simple, economical and easy to accept in both children and parents.