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目的：为进一步阐明炼焦工职业性肺癌的病因，寻求新型抗癌剂。方法：用小鼠作五环烃（苯并〔ａ〕芘、二苯并〔ａ，ｈ〕蒽）诱发肺癌的剂量－效应相关对比实验。结果：成功建立小动物肺癌模型，以ＤＢ〔ａ，ｈ〕Ａ诱发的肺癌率在５．０μｍｏｌ．ｋｇ－１组高达９０％以上，明显高于Ｂ［ａ］Ｐ，硒～沙棘抗癌复合剂在阻断肿瘤生成上具有一定的效果。结论：五环烃，尤其是ＤＢ［ａ，ｈ］Ａ，作为多环芳烃致癌原的代表，是炼焦工职业性肺癌的主要病因。
Objective: To seek further elucidation of the cause of occupational lung cancer in coking workers and seek new anticancer agents. METHODS: Dose-response correlation studies of lung cancer induced by pentacyclic hydrocarbons (benzo [a] pyrene, dibenzo [a, h] pyrene) were performed in mice. Results: A small animal model of lung cancer was successfully established. The rate of lung cancer induced by DB(a,h)A was 5.0 μmol. The kg-1 group was as high as 90%, which was significantly higher than B[a]P. Selenium-Seabuckthorn anticancer compound had a certain effect in blocking tumorigenesis. Conclusion: The pentacyclic hydrocarbons, especially DB[a,h]A, as the representatives of carcinogens of PAHs, are the main cause of occupational lung cancer in coking workers.