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目的探讨灵芝孢子油体内抗Friend鼠白血病病毒(Friend murine leukemia virus,Fr.MuLV)感染的疗效和作用机制。方法用Fr.MuLV感染BALB/C雌性小鼠,造模小鼠ig给药21d,比较各组动物的体质量、脾指数、胸腺指数,CD4+、CD8+、CD4+/CD8+等指标变化情况。结果小鼠感染Fr.MuLV后体质量严重减轻,脾明显肿大,胸腺萎缩,CD4+、CD8+、CD4+/CD8+值均显著降低。灵芝孢子油50、100、200mg/kg剂量均可显著改善体质量增长抑制、脾肿大及胸腺萎缩(P<0.01),100、200mg/kg剂量组CD4+、CD8+、CD4+/CD8+值均有明显升高(P<0.01、0.05)。结论灵芝孢子油对Fr.MuLV感染小鼠有保护作用,能够改善体质量增长抑制,抑制脾肿大及胸腺萎缩,升高感染小鼠的T淋巴细胞。
Objective To investigate the efficacy and mechanism of Ganoderma lucidum spore oil against Friend murine leukemia virus (Fr.MuLV) infection in vivo. Methods BALB / C female mice were infected with Fr.MuLV and the mice were given ig for 21 days. The body weight, spleen index, thymus index, CD4 +, CD8 + and CD4 + / CD8 + of the animals were compared. Results Fr.MuLV infection significantly reduced body weight, splenomegaly and thymus atrophy. The CD4 +, CD8 + and CD4 + / CD8 + levels were significantly decreased in mice. Ganoderma lucidum spores oil 50,100,200 mg / kg dose can significantly improve body weight growth inhibition, splenomegaly and thymus atrophy (P <0.01), 100,200 mg / kg dose group of CD4 +, CD8 +, CD4 + / CD8 + values were significantly Increased (P <0.01, 0.05). Conclusion Ganoderma lucidum spores oil has protective effect on Fr.MuLV infected mice, which can improve the inhibition of growth of body mass, inhibit splenomegaly and thymus atrophy, and increase the T lymphocytes of infected mice.