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记录细胞内电位发现四氧嘧啶具有激活和毒化胰岛B细胞的双相作用。在无或2.75mmol·L~(-1)葡萄糖时四氧嘧啶使B细胞膜去极化并诱发短暂的能被ATP敏感钾通道开放剂二氮嗪阻断的放电;在葡萄糖5.5或11.0mmol·L~(-1)时作用减轻或不明显。提示四氧嘧啶的激活作用与关闭ATP敏感的钾通道有关,而高葡萄糖能保护B细胞免受四氧嘧啶的损伤。
Recording intracellular potentials showed that alloxan has biphasic effects of activating and poisoning islet B cells. Alloxan depolarized the B cell membrane in the absence or 2.75 mmol·L -1 of glucose and induced transient discharges that were blocked by diazoxide, an ATP-sensitive potassium channel opener; at glucose 5.5 or 11.0 mmol · L ~ (-1) when the role of reduced or not obvious. It is suggested that the activation of alloxan is related to the shutdown of ATP-sensitive potassium channels, whereas high glucose protects B cells from alloxan injury.