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目的探讨复发性阿弗他溃疡患者肠道微生态改变及富硒粤航一号米对肠道菌群的调节作用。方法选择以稻米为主食,轻型复发性阿弗他溃疡,又符合中医辨证为脾虚的患者60例,分为两观察组,每组各30例,另外选择健康对照30例。观察1组主食稻米加入富硒粤航一号米,观察2组主食稻米为市售普通稻米,两观察组病例都含有健脾食材云苓、淮山、陈皮,实施饮食干预半年后作对比。结果两观察组复发性阿弗他溃疡患者存在肠道菌群失衡,表现为肠杆菌、肠球菌数量较对照组高,差异有显著性(P<0.01),双岐杆菌、乳酸杆菌、类杆菌数量较对照组低,差异有显著性(P<0.01),经饮食干预半年后,两观察组肠杆菌、肠球菌数量减少,与治疗前对比有显著差异(P<0.01),观察组1与观察组2治疗后双岐杆菌、乳酸杆菌、类杆菌数量的对比有差异(P<0.01)。结论脾虚型复发性阿弗他溃疡患者存在肠道菌群失衡,富硒粤航一号米能显著改善肠道菌群失衡。
Objective To investigate the changes of gut microecology in patients with recurrent aphthous ulcer and the regulatory effect of the selenium-enriched Cantonese No.1 meter on intestinal flora. Methods Sixty patients with rice-based recurrent aphthous ulcer and TCM syndrome differentiation of spleen deficiency were selected and divided into two observation groups, 30 cases in each group, and another 30 healthy controls. A group of staple rice was added to the first meter of selenium-enriched Yue-an. The two groups of staple rice were selected as normal rice. The two observation groups included Yunling, Yam-shan and Tanpi, respectively. Results There was an imbalance of intestinal microflora in patients with recurrent aphthous ulcer in the two observation groups. The numbers of enterobacteria and enterococci in the observation group were higher than those in the control group (P <0.01). Bifidobacterium, Lactobacillus, (P <0.01). After six months of dietary intervention, the numbers of Enterobacteriaceae and Enterococci in the two observation groups decreased significantly compared with those before treatment (P <0.01), and the difference between observation group 1 and control group There was a significant difference in the number of Bifidobacterium, Lactobacillus and Bacteroidetes in observation group 2 after treatment (P <0.01). Conclusion Spleen deficiency patients with recurrent aphthous ulcer exist imbalance of intestinal flora. Se-enriched Yue-1 rice can significantly improve intestinal flora imbalance.