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本实验观察了ＦＤＰ抗失血性休克作用。３组失血性休克大鼠分别接受５％ＦＤＰ溶液（Ａ组）、５％葡萄糖溶液（Ｂ组）和生理盐水（Ｃ组）静注。给药６０ｍｉｎ后，Ａ组ＭＡＰ为１０．４±２．１ｋＰａ，与Ｂ、Ｃ组７．９±２．４和７．７±２．６ｋＰａ间均有差异（Ｐ＜０．０１）；Ａ组动物存活率７５％，而Ｂ、Ｃ组分别为２５％和１５％（Ｐ＜０．０１）；Ａ组动脉血ｐＨ和ＰａＯ２分别为７．２４±０．１４和１３．４６±１．２２ｋＰａ，与Ｂ、Ｃ组７．１４±０．１４和１０．２９±３．８４ｋＰａ与７．０２±０．１０和７．２５±２．１２ｋＰａ间有显著差异（Ｐ＜０．０１）；Ａ组回输血液再灌流后血浆ＳＯＤ和ＭＤＡ分别为１２００±１２６Ｕｍｌ－１和０．４７±０．２５ｎｍｏｌｍｌ－１，同Ｂ、Ｃ组１０８１±１１９Ｕｍｌ－１和０．９１±０．２９ｎｍｏｌ－１与８３５±９Ｕｍｌ－１和１．１３±０．１６ｎｍｏｌ－１间均有显著差异（Ｐ＜０．０１）。结果表明ＦＤＰ保护组织损伤而产生抗休克作用。
The experiment observed the anti-hemorrhagic shock FDP role. Three groups of hemorrhagic shock rats received intravenous injection of 5% FDP solution (group A), 5% glucose solution (group B) and saline (group C) respectively. After 60 minutes of administration, MAP in group A was 10.4 ± 2.1 kPa, which was significantly lower than that in groups B and C (7.9 ± 2.4 vs 7.7 ± 2.6 kPa) (P <0.01); A The survival rate of animals in group A was 75%, while that in group B and C was 25% and 15%, respectively (P <0.01). The arterial blood pH and PaO2 in group A were 7.24 ± 0.14 and 13.46 ± 1, respectively. (P <0.01). There was a significant difference (P <0.01) between them at 22kPa and 7.14 ± 0.14 and 10.29 ± 3.84kPa, 7.02 ± 0.10 and 7.25 ± 2.12kPa in group B and C, respectively. Plasma levels of SOD and MDA were 1200 ± 126 Uml-1 and 0.47 ± 0.25 nmolml-1 in group A, respectively, and were similar to those in group B and group 1081 ± 119 Uml-1 and 0.91 ± 0.29 nmol-1 And 835 ± 9Uml-1 and 1.13 ± 0.16nmol-1 were significantly different (P <0.01). The results show that FDP protects tissue from injury and produces anti-shock effects.