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武汉部队总医院1979～1981年发现6例因服乙酰唑胺引起肾脏并发症。6例均为成年男性,均无各种泌尿系统疾病和磺胺类药物过敏史。肾脏并发症的表现如下:肾绞痛2例、结石排出1例、磺胺结晶排出1例、肾病综合症1例、急性肾功能衰竭死亡1例。乙酰唑胺所致肾脏并发症按 Parfitt 分类有二型,即Ⅰ型磺胺类药肾病和Ⅱ型结石形成。Ⅰ型临床上除因乙酰唑胺毒性或其乙酰化结晶堵塞,出现肾绞痛、腰酸痛、磺胺结晶尿、血尿、蛋白尿甚至无尿外,尚
From 1979 to 1981, Wuhan Military General Hospital found 6 cases of renal complications caused by taking acetazolamide. 6 cases were all adult men, no urinary system diseases and allergies to sulfa drugs. Renal complications were as follows: 2 cases of renal colic, 1 case of stone excretion, 1 case of sulfonamides, 1 case of nephrotic syndrome and 1 case of acute renal failure. Acetazolamide-induced renal complications according to Parfitt classification has two types, namely type Ⅰ sulfa drug-induced nephropathy and type II stone formation. In addition to clinical type Ⅰ acetazolamide or acetylation of crystalline blockage, renal colic, back pain, sulfa crystalline urine, hematuria, proteinuria and even without urine, yet