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细菌性阴道疾病(BV)与早产、晚期流产和产后感染有关。胰岛素样生长因子结合蛋白-1(IGFBP-1)是蜕膜内一种蛋白。其磷酸化对碘氧基苯甲醚(phosphorylated isoform,phIGFBP-1)由蜕膜产生,能用单克隆抗体6303查出。为观察phIGFBP-1能否是绒毛-蜕膜界面组织损伤的一种指示剂和妊娠妇女增加BV感染并发症危险的一种标志物,任意对照双盲观察妊娠期用阴道氯洁霉素治疗无症状的BV。对180例妊娠10～17周连续BV阳性妇女治疗前用宫颈拭子检查phlGFBP-1。全部淋球菌、沙眼衣原体阴性。BV诊断:用阴道涂片革兰氏染色,治疗开始后1周及妊娠33～36周复查。phIGFBP-1浓度测定用免疫酶法(immunoenzymometric aasay),达
Bacterial vaginosis (BV) is associated with preterm birth, late miscarriage and postpartum infection. Insulin-like growth factor binding protein-1 (IGFBP-1) is a protein found in the decidua. Its phosphorylated phosphorylated isoform (phIGFBP-1) is produced by the decidua and can be detected by the monoclonal antibody 6303. To observe whether phIGFBP-1 is a marker of tissue damage at the villi-decidua interface and a marker of increased risk of BV infection in pregnant women, randomized double-blind observation of vaginal clindamycin treatment during pregnancy Symptoms of BV. 180 cases of pregnancy 10 to 17 weeks of continuous BV positive women before treatment with cervical swab phlGFBP-1. All Neisseria gonorrhoeae, Chlamydia trachomatis negative. BV Diagnosis: Gram stain with a vaginal smear, 1 week after the start of treatment and 33 to 36 weeks of pregnancy. The concentration of phIGFBP-1 was measured by immunoenzymometric aasay