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脓毒症是由感染引起的全身炎性反应综合征,可发展为严重脓毒症和脓毒性休克。近年来,脓毒症的发生率在不断上升,其病死率高。同时脓毒症临床救治困难,并发症严重,可导致心肌抑制,且无特效治疗,究其原因是脓毒症心肌抑制的发病机制目前尚未明确。脓毒症心肌抑制的发病机制复杂,涉及组织、器官、细胞等多层面的因素,而目前分子机制方面的研究尤为受到关注,本文就此进行综述。
Sepsis is a systemic inflammatory response syndrome caused by infection that develops into severe sepsis and septic shock. In recent years, the incidence of sepsis is on the rise, with a high case fatality rate. At the same time, clinical treatment of sepsis difficult, serious complications, can lead to myocardial suppression, and no special treatment, the reason is that the pathogenesis of myocardial necrosis of sepsis is not yet clear. The pathogenesis of sepsis myocardial suppression is complex and involves many factors such as tissues, organs and cells. The current research on molecular mechanisms is of particular concern. This article reviews the current research.